Both the EV6 and ES have child safety locks to prevent children from opening the rear doors. The EV6 has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The ES’ child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
In the past twenty years hundreds of infants and young children have died after being left in vehicles, usually by accident. When turning the vehicle off, drivers of the EV6 are reminded to check the back seat if they opened the rear door before starting out. The ES doesn’t offer a back seat reminder.
In a Vehicle-to-Vehicle Frontal Crash Prevention 2.0 test conducted by the Insurance Institute for Highway Safety (IIHS), the Kia EV6 achieved a “Acceptable” rating - the second highest possible - for its performance in forward collision warning and automatic braking systems, demonstrating its excellent capabilities in preventing collisions. The Lexus ES has not been tested.
To help make backing out of a parking space safer, the EV6 has standard Rear Cross-Traffic Collision Warning with Rear Cross-Traffic Collision-Avoidance Assist, systems which detect vehicles approaching from the sides and can automatically apply the brakes to prevent a collision. Rear Cross-Traffic Braking costs extra on the ES.
Both the EV6 and the ES have standard driver and passenger frontal airbags, front and rear side-impact airbags, driver knee airbags, side-impact head airbags, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and available around view monitors.

